By coincidence rather than by design the Swiss chemist Albert Hofmann makes a sensational discovery in the spring of 1943. In the year the Atom bomb was built, this substance- LSD - was to become an A-bomb of the mind. Fractions of a milligram are enough to turn our framework of time and space upside down and ultimately change the modern world. Told using previously unreleased archive footage, with interviews from principal witnesses and Hofmann himself; The Substance is a fascinating investigation into our troubled relation with LSD.
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