Kayako's curse is still tormenting the residents of a Chicago building. Together with a young Japanese woman who holds the secret to ending the curse they confront the ghost together with horrifying consequences.
Kayako and Toshio's curse continues by haunting The Grudge 2's only survivor Jake (Matthew Knight) who is now confined to a psychiatric hospital after his family's alleged suicide. As Jake's case worker Dr. Sullivan (Shawnee Smith) investigates his Chicago home the curse continues to claim more victims. As the rage spreads it becomes clear that Jake's horrifying stories are true and that a mysterious Japanese woman might be the only hope of burying the Grudge that is unless she too becomes another victim.
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